|
Symbol Name ID |
Cd40lg
CD40 ligand MGI:88337 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
Autoimmune thrombocytopenia |
Lymphadenopathy |
Splenomegaly |
Keratitis |
Scleritis |
Lupus anticoagulant |
Platelet antibody positive |
| Disease(s) Associated with CD40LG | |||||||||||
| antiphospholipid syndrome | |||||||||||
| autoimmune thrombocytopenic purpura | |||||||||||
| multiple myeloma |
| Mouse Phenotypes | immune system phenotype |
abnormal osteoclast differentiation |
abnormal leukocyte adhesion |
increased splenocyte proliferation |
colitis |
enlarged spleen |
abnormal class switch recombination |
abnormal T cell differentiation |
abnormal T cell clonal deletion |
decreased double-positive T cell number |
increased CD4-positive, alpha-beta T cell number |
decreased regulatory T cell number |
microgliosis |
absent spleen germinal center |
increased splenocyte number |
decreased IgA level |
decreased IgD level |
decreased IgE level |
decreased IgG1 level |
increased IgG1 level |
decreased IgG2a level |
decreased IgG2b level |
decreased IgG3 level |
decreased IgG level |
increased IgG level |
decreased IgM level |
increased IgM level |
decreased immunoglobulin level |
abnormal T-helper 2 physiology |
abnormal immune system morphology |
abnormal immune system organ morphology |
abnormal bronchus-associated lymphoid tissue morphology |
abnormal lymph node morphology |
absent lymph node germinal center |
enlarged lymph nodes |
lymph node hypoplasia |
abnormal immune system physiology |
abnormal adaptive immunity |
abnormal antigen presentation |
increased interferon-gamma secretion |
decreased susceptibility to autoimmune diabetes |
increased autoantibody level |
increased anti-double stranded DNA antibody level |
increased anti-histone antibody level |
increased anti-single stranded DNA antibody level |
glomerulonephritis |
increased susceptibility to prion infection |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||
| Cd40lgm1Btlr/Cd40lgm1Btlr | * | |||||||||||||||||||||||||||||||||||||||||||||||
| Cd40lgtm1Flv/Cd40lgtm1Flv | ||||||||||||||||||||||||||||||||||||||||||||||||
| Cd40lgtm1Imx/Cd40lgtm1Imx | ||||||||||||||||||||||||||||||||||||||||||||||||
| Cd40lgm1Btlr/Y | * | |||||||||||||||||||||||||||||||||||||||||||||||
| Cd40lgtm1Imx/Y | * | |||||||||||||||||||||||||||||||||||||||||||||||
| Tg(Igh-V-CD40lg)#Tsub/0 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Cd40lgtm1Parl/Cd40lgtm1Parl Tg(Cd4-cre)1Cwi/0 (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||||||||
| Cd40lgtm1Parl/Cd40lgtm1Parl Commd10Tg(Vav1-icre)A2Kio/Commd10+ (conditional) |
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| Cd40lgtm1Parl/Cd40lgtm1Parl Tg(Tek-cre)1Ywa/0 (conditional) |
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| Cd40lgtm1Parl/Y Commd10Tg(Vav1-icre)A2Kio/Commd10+ (conditional) |
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| Cd40lgtm1Parl/Y Tg(Cd4-cre)1Cwi/0 (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||||||||
| Cd40lgtm1Parl/Y Tg(Tek-cre)1Ywa/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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